# OnCo record base-excision-repair-parp (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/base-excision-repair-parp/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "base-excision-repair-parp" ;
  schema:name "Base excision repair, PARP & alkylation damage"@en ;
  schema:description "Tens of thousands of times a day a single DNA letter is oxidised or chemically scarred. A small crew snips it out and PARP marks the nick so it gets sealed. PARP inhibitors do not just switch PARP off; they trap it on the DNA, turning a harmless nick into a lethal break when the cell copies its DNA."@en ;
  schema:url <https://onco.cc/pathways/base-excision-repair-parp/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Base_excision_repair> ;
  schema:citation <https://doi.org/10.1038/nrg2380>, <https://doi.org/10.1126/science.aam7344> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/parp-pet/>, <https://onco.cc/technologies/radionuclide-parp-combination/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:targets <https://onco.cc/targets/parp/>, <https://onco.cc/targets/brca/>, <https://onco.cc/targets/atr/> ;
  onco:drugs <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/niraparib/>, <https://onco.cc/drugs/rucaparib/>, <https://onco.cc/drugs/talazoparib/>, <https://onco.cc/drugs/temozolomide/>, <https://onco.cc/drugs/lomustine/> ;
  onco:pathways <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/homologous-recombination-repair/>, <https://onco.cc/pathways/cgas-sting/>, <https://onco.cc/pathways/replication-stress/> ;
  onco:terms <https://onco.cc/terms/mgmt/>, <https://onco.cc/terms/synthetic-lethality/>, <https://onco.cc/terms/hrd/>, <https://onco.cc/terms/dna-alkylator-payloads/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-lord-science/>, <https://onco.cc/key-papers/paper-caldecott-nat-rev-genet/> .