# OnCo record bcl2-g101v (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/bcl2-g101v/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "bcl2-g101v" ;
  schema:name "BCL2 G101V and the other venetoclax binding-site mutations"@en ;
  schema:alternateName "BCL2 Gly101Val"@en, "BCL2 G101V"@en, "venetoclax resistance mutation"@en, "BCL2 D103Y"@en ;
  schema:description "A change in the pocket of the survival protein BCL-2 where venetoclax has to fit. The protein still works and the drug no longer binds it. It can be detected in blood months before the disease starts growing again."@en ;
  schema:url <https://onco.cc/biomarkers/bcl2-g101v/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-18-1119> ;
  onco:tag "biomarker", "resistance", "lymphoma" ;
  onco:related <https://onco.cc/biomarkers/btk-c481s/>, <https://onco.cc/biomarkers/bcl2-rearrangement/> ;
  onco:cancers <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/mantle-cell-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/mcl1/> ;
  onco:drugs <https://onco.cc/drugs/venetoclax/>, <https://onco.cc/drugs/sonrotoclax/> ;
  onco:pathways <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/resistance-routes-map/> ;
  onco:terms <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/terms/mrd/> .