# OnCo record bcl2-rearrangement (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/bcl2-rearrangement/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "bcl2-rearrangement" ;
  schema:name "BCL2 rearrangement, t(14;18)"@en ;
  schema:alternateName "t(14;18)"@en, "IGH::BCL2"@en, "BCL2 translocation"@en, "BCL2 break-apart FISH"@en, "bcl-2 rearrangement"@en ;
  schema:description "A swap of DNA that puts the survival gene BCL2 next to an antibody gene, so the cell makes far too much of a protein that stops it dying. It is the founding event of most follicular lymphomas and it happens in the bone marrow, often years before anything is wrong."@en ;
  schema:url <https://onco.cc/biomarkers/bcl2-rearrangement/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1126/science.3929382>, <https://doi.org/10.1182/blood-2012-06-435842> ;
  onco:tag "biomarker", "lymphoma" ;
  onco:related <https://onco.cc/biomarkers/double-hit-rearrangement/>, <https://onco.cc/biomarkers/myc-bcl2-double-expressor/> ;
  onco:cancers <https://onco.cc/cancers/follicular-lymphoma/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/cytogenetics-fish/>, <https://onco.cc/technologies/histopathology-ihc/> ;
  onco:targets <https://onco.cc/targets/bcl2/> ;
  onco:drugs <https://onco.cc/drugs/venetoclax/> ;
  onco:pathways <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/germinal-centre-reaction/> ;
  onco:terms <https://onco.cc/terms/fish/>, <https://onco.cc/terms/cytogenetics/>, <https://onco.cc/terms/lymphoma-bio-germinal-centre/> .