# OnCo record bcl2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/bcl2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "bcl2" ;
  schema:name "BCL-2"@en ;
  schema:description "A protein that stops cells from self-destructing. Venetoclax removes that protection and has transformed leukaemia treatment."@en ;
  schema:url <https://onco.cc/targets/bcl2/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Bcl-2>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:990>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171791>, <https://www.uniprot.org/uniprotkb/P10415/entry>, <https://www.ncbi.nlm.nih.gov/gene/596> ;
  owl:sameAs <http://www.wikidata.org/entity/Q425201> ;
  schema:citation <https://en.wikipedia.org/wiki/Bcl-2>, <https://doi.org/10.1126/science.3929382>, <https://doi.org/10.1182/blood-2012-06-435842>, <https://doi.org/10.1073/pnas.79.24.7824>, <https://doi.org/10.1200/JCO.2011.41.0985>, <https://doi.org/10.1038/s41375-022-01620-2> ;
  onco:tag "apoptosis" ;
  schema:alternateName "BCL2" ;
  onco:targetClass "other" ;
  onco:firstDescribed "1986"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/bcl2-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/sonrotoclax/>, <https://onco.cc/drugs/venetoclax/> ;
  onco:pathways <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/basal-cell-carcinoma-signalling/>, <https://onco.cc/pathways/micrornas-in-cancer/>, <https://onco.cc/pathways/sclc-signalling/>, <https://onco.cc/pathways/myc/>, <https://onco.cc/pathways/transcription-addiction/> .