# OnCo record bcr-abl (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/bcr-abl/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "bcr-abl" ;
  schema:name "BCR::ABL1 (Philadelphia chromosome)"@en ;
  schema:description "The fusion that defines chronic myeloid leukaemia and a quarter of adult acute lymphoblastic leukaemia; the first cancer driver ever switched off by a pill."@en ;
  schema:url <https://onco.cc/targets/bcr-abl/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Philadelphia_chromosome> ;
  owl:sameAs <http://www.wikidata.org/entity/Q1129111> ;
  schema:citation <https://en.wikipedia.org/wiki/Philadelphia_chromosome> ;
  onco:tag "driver", "fusion", "kinase" ;
  schema:alternateName "BCR-ABL1" ;
  onco:targetClass "kinase" ;
  onco:related <https://onco.cc/biomarkers/bcr-abl1-transcript/>, <https://onco.cc/biomarkers/bcr-abl1-t315i/> ;
  onco:cancers <https://onco.cc/cancers/all-leukemia/> ;
  onco:drugs <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/ponatinib/>, <https://onco.cc/drugs/dasatinib/>, <https://onco.cc/drugs/asciminib/>, <https://onco.cc/drugs/omacetaxine/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/bcr-abl1-signalling/>, <https://onco.cc/pathways/cml-signalling/> .