# OnCo record bcr-abl1-signalling (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/bcr-abl1-signalling/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "bcr-abl1-signalling" ;
  schema:name "BCR::ABL1 (Philadelphia chromosome)"@en ;
  schema:description "Chronic myeloid leukaemia is caused by one broken gene: two chromosomes swap pieces and glue a kinase (ABL1) to a protein that forces it permanently on. Imatinib, the first drug to target it, turned a fatal disease into a manageable one, and later drugs cover the mutations that escape it."@en ;
  schema:url <https://onco.cc/pathways/bcr-abl1-signalling/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Philadelphia_chromosome> ;
  schema:citation <https://en.wikipedia.org/wiki/Philadelphia_chromosome> ;
  onco:cancers <https://onco.cc/cancers/cml/>, <https://onco.cc/cancers/all-leukemia/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/pik3ca/>, <https://onco.cc/targets/abl1/> ;
  onco:drugs <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/dasatinib/>, <https://onco.cc/drugs/nilotinib/>, <https://onco.cc/drugs/bosutinib/>, <https://onco.cc/drugs/ponatinib/>, <https://onco.cc/drugs/asciminib/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/jak-stat/> .