# OnCo record bcr-abl1-transcript (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/bcr-abl1-transcript/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "bcr-abl1-transcript" ;
  schema:name "BCR::ABL1 transcript (Philadelphia chromosome, quantitative PCR)"@en ;
  schema:alternateName "BCR-ABL1"@en, "BCR::ABL1"@en, "BCR-ABL"@en, "Philadelphia chromosome positive"@en, "Ph+"@en, "Ph-positive"@en, "BCR-ABL1 IS"@en, "BCR-ABL1 international scale"@en, "MMR"@en, "MR4"@en, "MR4.5"@en, "major molecular response"@en ;
  schema:description "The BCR::ABL1 fusion is the Philadelphia chromosome that defines chronic myeloid leukaemia and some acute lymphoblastic leukaemia. Its transcript level in blood, on the international scale, is how response to tyrosine kinase inhibitors is measured and when treatment can be stopped."@en ;
  schema:url <https://onco.cc/biomarkers/bcr-abl1-transcript/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=211ef2da-2868-4a77-8055-1cb2cd78e24b>, <https://www.fda.gov/medical-devices/in-vitro-diagnostics/list-cleared-or-approved-companion-diagnostic-devices-in-vitro-and-imaging-tools> ;
  onco:tag "biomarker", "cml" ;
  onco:related <https://onco.cc/biomarkers/bcr-abl1-t315i/> ;
  onco:cancers <https://onco.cc/cancers/cml/>, <https://onco.cc/cancers/cml-chronic-phase/>, <https://onco.cc/cancers/cml-advanced-phase/>, <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/all-paediatric-ph-positive/> ;
  onco:drugs <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/dasatinib/>, <https://onco.cc/drugs/nilotinib/>, <https://onco.cc/drugs/bosutinib/>, <https://onco.cc/drugs/ponatinib/>, <https://onco.cc/drugs/asciminib/> ;
  onco:terms <https://onco.cc/terms/philadelphia-chromosome/>, <https://onco.cc/terms/molecular-response/>, <https://onco.cc/terms/mrd/> .