# OnCo record beacon-crc (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/beacon-crc/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "beacon-crc", "NCT02928224" ;
  schema:name "BEACON CRC"@en ;
  schema:description "BEACON was the first trial to show that blocking BRAF works in bowel cancer once the escape route through EGFR is blocked too: encorafenib with cetuximab lengthened life and shrank ten times as many tumours as chemotherapy."@en ;
  schema:url <https://onco.cc/trials/beacon-crc/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02928224>, <https://doi.org/10.1056/NEJMoa1908075>, <https://doi.org/10.1200/JCO.20.02088> ;
  onco:status "positive" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/braf-v600e-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:targets <https://onco.cc/targets/braf/>, <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/mek/> ;
  onco:drugs <https://onco.cc/drugs/encorafenib/>, <https://onco.cc/drugs/binimetinib/>, <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/folfiri/>, <https://onco.cc/drugs/irinotecan/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:people <https://onco.cc/people/scott-kopetz/>, <https://onco.cc/people/josep-tabernero/>, <https://onco.cc/people/elena-elez/> .