# OnCo record bicalutamide (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/bicalutamide/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "bicalutamide" ;
  schema:name "Bicalutamide"@en ;
  schema:description "The old antiandrogen pill used to block the testosterone flare from GnRH agonists and in combined androgen blockade; superseded by enzalutamide-class drugs."@en ;
  schema:url <https://onco.cc/drugs/bicalutamide/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Bicalutamide> ;
  owl:sameAs <http://www.wikidata.org/entity/Q1988832> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=bicalutamide> ;
  onco:status "approved" ;
  onco:tag "gap-fill", "generic" ;
  onco:modality "Oral first-generation non-steroidal antiandrogen" ;
  schema:alternateName "Casodex" ;
  onco:approval "US 1995: Metastatic prostate cancer with LHRH analogue", "EU 1995: Advanced prostate cancer; 150 mg for locally advanced" ;
  onco:acceleratedApproval "US 1995-10-04: In combination with an LHRH analogue for advanced prostate cancer" ;
  onco:acceleratedApprovalConfirmed "US 1997-12-12: In combination with an LHRH analogue for advanced prostate cancer" ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/salivary-duct-carcinoma/>, <https://onco.cc/cancers/tnbc/> ;
  onco:technologies <https://onco.cc/technologies/androgen-deprivation/> ;
  onco:targets <https://onco.cc/targets/androgen-receptor/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/> ;
  onco:pathways <https://onco.cc/pathways/ar-signaling/> ;
  onco:trials <https://onco.cc/trials/rtog-9601/>, <https://onco.cc/trials/nct02531516/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-gucalp-bicalutamide-ar-positive-tbcrc011-ccr-2013/> .