# OnCo record bim (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/bim/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "bim" ;
  schema:name "BIM (BCL2L11)"@en ;
  schema:alternateName "BIM"@en, "BH3-only protein BIM"@en, "BH3"@en, "BimEL"@en, "BimL"@en, "BimS"@en, "BCL2 like 11"@en, "BCL2L11" ;
  schema:description "BIM is a pro-death protein that leukaemia cells keep clamped by BCL-2. Venetoclax and sonrotoclax are BH3 mimetics: they copy the part of BIM that binds BCL-2, so BIM is released, the mitochondria leak and the cell dies."@en ;
  schema:url <https://onco.cc/targets/bim/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:994>, <https://www.uniprot.org/uniprotkb/O43521/entry>, <https://www.ncbi.nlm.nih.gov/gene/10018> ;
  onco:tag "wave5-target" ;
  onco:targetClass "other" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:994>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153094>, <https://www.uniprot.org/uniprotkb/O43521/entry>, <https://www.ncbi.nlm.nih.gov/gene/10018> ;
  onco:related <https://onco.cc/drugs/venetoclax/>, <https://onco.cc/drugs/sonrotoclax/>, <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/bax/> ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/dlbcl/> ;
  onco:technologies <https://onco.cc/technologies/bcl2-inhibitors/> ;
  onco:pathways <https://onco.cc/pathways/apoptosis-bcl2/> .