# OnCo record binimetinib (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/binimetinib/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "binimetinib" ;
  schema:name "Binimetinib"@en ;
  schema:description "Binimetinib is the MEK inhibitor partnered with encorafenib; blocking the next step in the same relay stops the tumour rerouting around the BRAF block."@en ;
  schema:url <https://onco.cc/drugs/binimetinib/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Binimetinib> ;
  owl:sameAs <http://www.wikidata.org/entity/Q19903515> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Binimetinib> ;
  onco:status "approved" ;
  onco:modality "Small-molecule kinase inhibitor (MEK1/2)" ;
  schema:alternateName "Mektovi" ;
  onco:approval "US 2018: BRAF V600E/K melanoma with encorafenib", "US 2023: BRAF V600E metastatic NSCLC with encorafenib" ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/braf-v600e-nsclc/>, <https://onco.cc/cancers/braf-v600-melanoma/>, <https://onco.cc/cancers/advanced-melanoma/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/encorafenib/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/ocular-toxicity/> ;
  onco:trials <https://onco.cc/trials/columbus/>, <https://onco.cc/trials/nct05270044/>, <https://onco.cc/trials/nct04657991/>, <https://onco.cc/trials/nct03947385/>, <https://onco.cc/trials/nct05195632/> .