# OnCo record bioelectric-theory-of-cancer (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/bioelectric-theory-of-cancer/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "bioelectric-theory-of-cancer" ;
  schema:name "Bioelectric theory of cancer (Levin)"@en ;
  schema:alternateName "bioelectric theory"@en, "bioelectricity and cancer"@en, "membrane potential and cancer"@en, "resting potential hypothesis"@en, "cancer as a disorder of bioelectric patterning"@en, "oncochannels"@en ;
  schema:description "Cells hold a voltage across their membranes, and tissues share these voltages as patterns that guide growth and regeneration. Michael Levin proposes that cancer is a breakdown of this pattern: tumour cells are depolarised, and in tadpoles restoring the voltage with light-controlled ion channels prevented and reversed tumours caused by mutant KRAS. Striking animal results; no human evidence yet."@en ;
  schema:url <https://onco.cc/terms/bioelectric-theory-of-cancer/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Bioelectricity> ;
  schema:citation <https://doi.org/10.18632/oncotarget.8036>, <https://doi.org/10.1242/dmm.010835>, <https://doi.org/10.1016/j.cell.2021.02.034>, <https://doi.org/10.1038/s41586-019-1563-y>, <https://doi.org/10.1038/s41586-019-1564-x> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/tissue-organisation-field-theory/>, <https://onco.cc/terms/mechanical-theory-of-cancer/>, <https://onco.cc/terms/epigenetic-progenitor-theory/>, <https://onco.cc/terms/somatic-mutation-theory/>, <https://onco.cc/pathways/cancer-neuroscience/>, <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/targets/kras/>, <https://onco.cc/technologies/ttfields/>, <https://onco.cc/cancers/glioblastoma/> ;
  onco:cancers <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/melanoma/> ;
  onco:technologies <https://onco.cc/technologies/ttfields/> ;
  onco:targets <https://onco.cc/targets/kras/> ;
  onco:pathways <https://onco.cc/pathways/cancer-neuroscience/>, <https://onco.cc/pathways/ras-mapk/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-venkatesh-nature/>, <https://onco.cc/key-papers/paper-levin-cell/>, <https://onco.cc/key-papers/paper-venkataramani-nature/>, <https://onco.cc/key-papers/paper-chernet-dis-model-mech/>, <https://onco.cc/key-papers/paper-chernet-oncotarget/> .