# OnCo record blood-brain-barrier-metastasis (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/blood-brain-barrier-metastasis/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "blood-brain-barrier-metastasis" ;
  schema:name "The blood-brain barrier & brain metastasis"@en ;
  schema:description "The brain's blood vessels are sealed tight and fitted with pumps that eject most drugs. That protects the brain from poisons but also from chemotherapy and antibodies. Cancer cells that do squeeze through recruit the brain's own support cells, astrocytes, to feed and shield them."@en ;
  schema:url <https://onco.cc/pathways/blood-brain-barrier-metastasis/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Blood–brain_barrier> ;
  schema:citation <https://doi.org/10.1038/nature18268> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/glioblastoma/> ;
  onco:technologies <https://onco.cc/technologies/bbb-focused-ultrasound/>, <https://onco.cc/technologies/litt/>, <https://onco.cc/technologies/sbrt/>, <https://onco.cc/technologies/prophylactic-cranial-irradiation/>, <https://onco.cc/technologies/mri/>, <https://onco.cc/technologies/glioma-car-t/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/alk/>, <https://onco.cc/targets/her2/>, <https://onco.cc/targets/akt/> ;
  onco:drugs <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/lorlatinib/>, <https://onco.cc/drugs/alectinib/>, <https://onco.cc/drugs/tucatinib/>, <https://onco.cc/drugs/trastuzumab-deruxtecan/>, <https://onco.cc/drugs/temozolomide/>, <https://onco.cc/drugs/lomustine/>, <https://onco.cc/drugs/capivasertib/> ;
  onco:pathways <https://onco.cc/pathways/organ-tropism-seed-soil/>, <https://onco.cc/pathways/cgas-sting/>, <https://onco.cc/pathways/cancer-neuroscience/>, <https://onco.cc/pathways/drug-efflux-pumps/>, <https://onco.cc/pathways/metastatic-cascade/> ;
  onco:terms <https://onco.cc/terms/blood-brain-barrier/>, <https://onco.cc/terms/her2-brain-metastases/>, <https://onco.cc/terms/efflux-pump/>, <https://onco.cc/terms/mgmt/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-brain-delivery/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-chen-nature-2016/> .