# OnCo record bolt (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/bolt/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "bolt", "NCT01327053" ;
  schema:name "BOLT"@en ;
  schema:description "BOLT showed that sonidegib, a second hedgehog pathway pill, shrinks about four in ten locally advanced basal cell carcinomas at its lower dose, and that the higher dose adds side effects rather than responses."@en ;
  schema:url <https://onco.cc/trials/bolt/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01327053>, <https://doi.org/10.1016/S1470-2045(15)70100-2> ;
  onco:status "positive" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/locally-advanced-bcc/>, <https://onco.cc/cancers/basal-cell-carcinoma/> ;
  onco:technologies <https://onco.cc/technologies/hedgehog-inhibitors/> ;
  onco:targets <https://onco.cc/targets/smoothened/> ;
  onco:drugs <https://onco.cc/drugs/sonidegib/> ;
  onco:companies <https://onco.cc/companies/novartis/>, <https://onco.cc/companies/sun-pharma/> ;
  onco:pathways <https://onco.cc/pathways/hedgehog/>, <https://onco.cc/pathways/basal-cell-carcinoma-signalling/> ;
  onco:people <https://onco.cc/people/reinhard-dummer/> .