# OnCo record bone-modifying-agents (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/bone-modifying-agents/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "bone-modifying-agents" ;
  schema:name "Bone-modifying agents (bisphosphonates, denosumab)"@en ;
  schema:description "Zoledronic acid and denosumab reduce fractures, spinal cord compression and bone pain from bone metastases and myeloma, prevent treatment-induced bone loss, and in postmenopausal breast cancer modestly reduce recurrence in bone."@en ;
  schema:url <https://onco.cc/technologies/bone-modifying-agents/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Bisphosphonate> ;
  owl:sameAs <http://www.wikidata.org/entity/Q412205> ;
  schema:citation <https://doi.org/10.1016/S0140-6736(15)60908-4>, <https://doi.org/10.1200/JCO.2017.75.4614> ;
  onco:status "standard-of-care" ;
  onco:tag "gap-fill", "supportive" ;
  onco:cancers <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/rcc/> ;
  onco:sections <https://onco.cc/fronts/supportive-care/>, <https://onco.cc/fronts/rejuvenation/> ;
  onco:technologies <https://onco.cc/technologies/pain-management/>, <https://onco.cc/technologies/palliative-radiotherapy/>, <https://onco.cc/technologies/survivorship-care-plan/>, <https://onco.cc/technologies/cancer-treatment-bone-loss/> ;
  onco:drugs <https://onco.cc/drugs/radium-223/> ;
  onco:companies <https://onco.cc/companies/outperform-cancer/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-early-breast-cancer-trialists-collaborative-group-ebctcg-lancet/>, <https://onco.cc/key-papers/paper-van-poznak-j-clin-oncol/> .