# OnCo record bortezomib (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/bortezomib/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "bortezomib" ;
  schema:name "Bortezomib"@en ;
  schema:description "Bortezomib was the first proteasome inhibitor: it jams the cell's protein-recycling machine, which antibody-factory plasma cells cannot tolerate."@en ;
  schema:url <https://onco.cc/drugs/bortezomib/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Bortezomib> ;
  owl:sameAs <http://www.wikidata.org/entity/Q419319> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Bortezomib> ;
  onco:status "approved" ;
  onco:modality "Proteasome inhibitor" ;
  schema:alternateName "Velcade" ;
  onco:approval "US 2003: Relapsed myeloma (accelerated)", "US 2008: Newly diagnosed myeloma" ;
  onco:acceleratedApproval "US 2003-05-13: Multiple myeloma patients who received at least two prior therapies and demontrated disease progression on the last therapy" ;
  onco:acceleratedApprovalConfirmed "US 2005-03-25: Multiple myeloma patients who received at least two prior therapies and demontrated disease progression on the last therapy" ;
  onco:related <https://onco.cc/technologies/green-tea-egcg/> ;
  onco:cancers <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/myeloma-transplant-eligible/>, <https://onco.cc/cancers/plasma-cell-leukaemia/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:companies <https://onco.cc/companies/takeda/>, <https://onco.cc/companies/johnson-johnson/> ;
  onco:pathways <https://onco.cc/pathways/ubiquitin-proteasome-system/> ;
  onco:trials <https://onco.cc/trials/nct06868654/>, <https://onco.cc/trials/nct06464991/>, <https://onco.cc/trials/nct06956170/>, <https://onco.cc/trials/nct05572515/>, <https://onco.cc/trials/nct05623020/>, <https://onco.cc/trials/nct06152575/>, <https://onco.cc/trials/nct05519085/>, <https://onco.cc/trials/nct04975997/>, <https://onco.cc/trials/nct06413498/>, <https://onco.cc/trials/nct06158841/>, <https://onco.cc/trials/nct06208150/>, <https://onco.cc/trials/nct06868667/>, <https://onco.cc/trials/nct02343042/>, <https://onco.cc/trials/nct03314181/>, <https://onco.cc/trials/nct04414475/>, <https://onco.cc/trials/nct04133636/>, <https://onco.cc/trials/nct03989414/>, <https://onco.cc/trials/nct04068597/>, <https://onco.cc/trials/nct06577025/>, <https://onco.cc/trials/nct07227311/>, <https://onco.cc/trials/nct07018050/>, <https://onco.cc/trials/nct02773030/> .