# OnCo record braf-plus-mek (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/braf-plus-mek/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "braf-plus-mek" ;
  schema:name "BRAF inhibitor + MEK inhibitor"@en ;
  schema:description "Blocking two consecutive steps in the same relay prevents the pathway from rerouting and reduces side effects."@en ;
  schema:url <https://onco.cc/pairings/braf-plus-mek/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01909453> ;
  onco:cancers <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/nsclc/> ;
  onco:drugs <https://onco.cc/drugs/encorafenib/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:pairs <https://onco.cc/targets/braf/>, <https://onco.cc/pathways/ras-mapk/> .