# OnCo record brca-reversion-mutations (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/brca-reversion-mutations/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "brca-reversion-mutations" ;
  schema:name "BRCA reversion mutations"@en ;
  schema:alternateName "reversion mutation"@en, "reversion mutations"@en, "BRCA reversion"@en, "BRCA1 reversion"@en, "BRCA2 reversion"@en, "secondary BRCA mutation"@en, "restored homologous recombination"@en, "homologous recombination restoration"@en, "PARP inhibitor resistance mutation"@en, "acquired PARP inhibitor resistance"@en, "reversion to platinum resistance"@en ;
  schema:description "A cancer with a broken BRCA gene can repair the break itself under the pressure of PARP inhibitors or platinum: a second mutation restores the reading frame, the DNA-repair machinery switches back on, and both drugs stop working. Reversion mutations show up in blood ctDNA in a fifth to a third of resistant cases and mean it is time for a different class of treatment."@en ;
  schema:url <https://onco.cc/terms/brca-reversion-mutations/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  onco:related <https://onco.cc/terms/gbrca-mutation/>, <https://onco.cc/terms/hrd/>, <https://onco.cc/targets/brca/>, <https://onco.cc/targets/parp/>, <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/niraparib/>, <https://onco.cc/drugs/rucaparib/>, <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/platinum-sensitivity/> ;
  onco:cancers <https://onco.cc/cancers/platinum-sensitive-ovarian-cancer/>, <https://onco.cc/cancers/platinum-resistant-ovarian-cancer/>, <https://onco.cc/cancers/high-grade-serous-ovarian-cancer/>, <https://onco.cc/cancers/prostate-mcrpc/> .