# OnCo record brca (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/brca/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "brca" ;
  schema:name "BRCA1 / BRCA2 (HRD)"@en ;
  schema:description "DNA repair genes. Inheriting a broken copy raises breast and ovarian cancer risk, but tumours that lose them become uniquely vulnerable to PARP inhibitors and platinum."@en ;
  schema:url <https://onco.cc/targets/brca/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/BRCA_mutation> ;
  owl:sameAs <http://www.wikidata.org/entity/Q4836333> ;
  schema:citation <https://en.wikipedia.org/wiki/BRCA_mutation> ;
  onco:tag "germline", "biomarker" ;
  schema:alternateName "BRCA1, BRCA2" ;
  onco:targetClass "tumor-suppressor" ;
  onco:related <https://onco.cc/pairings/platinum-plus-hrd/>, <https://onco.cc/biomarkers/brca-germline/>, <https://onco.cc/biomarkers/brca-somatic/>, <https://onco.cc/biomarkers/hrd-positive/> ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/gallbladder/> ;
  onco:drugs <https://onco.cc/drugs/bracanalysis-cdx/>, <https://onco.cc/drugs/mychoice-cdx/>, <https://onco.cc/drugs/olaparib/>, <https://onco.cc/drugs/rucaparib/>, <https://onco.cc/drugs/talazoparib/> ;
  onco:pathways <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/breast-cancer-signalling/>, <https://onco.cc/pathways/pancreatic-cancer-signalling/> ;
  onco:terms <https://onco.cc/terms/gbrca-mutation/>, <https://onco.cc/terms/hrd/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-couch-tnbc-germline-17-genes-jco-2015/>, <https://onco.cc/key-papers/paper-sharma-tnbc-registry-germline-brca-bcrt-2014/>, <https://onco.cc/key-papers/paper-hahnen-geparsixto-germline-brca-jama-oncol-2017/>, <https://onco.cc/key-papers/paper-shimelis-tnbc-risk-genes-jnci-2018/>, <https://onco.cc/key-papers/paper-staaf-tnbc-whole-genome-scan-b-nat-med-2019/>, <https://onco.cc/key-papers/paper-bertucci-metastatic-breast-genomics-nature-2019/>, <https://onco.cc/key-papers/paper-hu-germline-mutations-pancreatic-cancer-risk-jama-2018/>, <https://onco.cc/key-papers/paper-shindo-germline-sporadic-pancreatic-jco-2017/>, <https://onco.cc/key-papers/paper-yurgelun-germline-second-hits-resected-pancreatic-genet-med-2019/>, <https://onco.cc/key-papers/paper-golan-brca-pancreatic-platinum-survival-bjc-2014/>, <https://onco.cc/key-papers/paper-polo-olaparib-maintenance-gbrca-pancreatic-nejm-2019/>, <https://onco.cc/key-papers/paper-lowery-prospective-germline-exocrine-pancreatic-jnci-2018/>, <https://onco.cc/key-papers/paper-giraldo-gallbladder-msk-impact-ccr-2022/>, <https://onco.cc/key-papers/paper-wardell-biliary-drivers-germline-j-hepatol-2018/>, <https://onco.cc/key-papers/paper-weinberg-biliary-profiling-jgo-2019/>, <https://onco.cc/key-papers/paper-pritchard-inherited-dna-repair-metastatic-prostate-nejm-2016/>, <https://onco.cc/key-papers/paper-abida-triton2-rucaparib-brca-jco-2020/>, <https://onco.cc/key-papers/paper-castro-germline-brca-prostate-outcomes-jco-2013/> .