# OnCo record breakwater (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/breakwater/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "breakwater", "NCT04607421" ;
  schema:name "BREAKWATER"@en ;
  schema:description "Doubled survival, from about 15 to about 30 months, in the worst-prognosis genetic subtype of bowel cancer by adding two targeted drugs to first-line chemotherapy."@en ;
  schema:url <https://onco.cc/trials/breakwater/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04607421>, <https://ascopubs.org/doi/10.1200/JCO.2025.43.17_suppl.LBA3500>, <https://ascopubs.org/doi/10.1200/JCO.2026.44.17_suppl.LBA3503> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2020-12-21" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/braf-v600e-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/braf/>, <https://onco.cc/targets/egfr/> ;
  onco:drugs <https://onco.cc/drugs/encorafenib/>, <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/folfox/>, <https://onco.cc/drugs/folfiri/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/project-frontrunner/> ;
  onco:trials <https://onco.cc/trials/swog-s1406/> ;
  onco:people <https://onco.cc/people/scott-kopetz/>, <https://onco.cc/people/elena-elez/>, <https://onco.cc/people/josep-tabernero/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-jones-non-v600-braf-colorectal-jco-2017/>, <https://onco.cc/key-papers/paper-breakwater-nat-med-2025/> .