# OnCo record bruin-cll-321 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/bruin-cll-321/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "bruin-cll-321", "NCT04666038" ;
  schema:name "BRUIN CLL-321"@en ;
  schema:description "The randomised trial that confirmed pirtobrutinib works after other BTK inhibitors fail, leading to full approval in December 2025."@en ;
  schema:url <https://onco.cc/trials/bruin-cll-321/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04666038> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2021-03-09" ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/cll-relapsed/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/btk/> ;
  onco:drugs <https://onco.cc/drugs/pirtobrutinib/> ;
  onco:companies <https://onco.cc/companies/eli-lilly/> ;
  onco:people <https://onco.cc/people/jennifer-brown/> .