# OnCo record btk (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/btk/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "btk" ;
  schema:name "BTK (Bruton tyrosine kinase)"@en ;
  schema:description "The signalling enzyme that B-cell cancers use to survive. Blocking it turned chronic lymphocytic leukaemia into a disease controlled by a daily pill."@en ;
  schema:url <https://onco.cc/targets/btk/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Bruton%27s_tyrosine_kinase>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1133>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000010671>, <https://www.uniprot.org/uniprotkb/Q06187/entry>, <https://www.ncbi.nlm.nih.gov/gene/695> ;
  owl:sameAs <http://www.wikidata.org/entity/Q423572> ;
  schema:citation <https://en.wikipedia.org/wiki/Bruton%27s_tyrosine_kinase>, <https://doi.org/10.1038/nature08638> ;
  onco:tag "kinase" ;
  schema:alternateName "BTK" ;
  onco:targetClass "kinase" ;
  onco:firstDescribed "1993"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:drugs <https://onco.cc/drugs/ibrutinib/>, <https://onco.cc/drugs/acalabrutinib/>, <https://onco.cc/drugs/zanubrutinib/>, <https://onco.cc/drugs/pirtobrutinib/>, <https://onco.cc/drugs/bgb-16673/>, <https://onco.cc/drugs/nemtabrutinib/>, <https://onco.cc/drugs/bexobrutideg/> ;
  onco:pathways <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/bcr-signalling/>, <https://onco.cc/pathways/inflammation-nfkb/> .