# OnCo record btki-ibrutinib-cardiac-caution (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/btki-ibrutinib-cardiac-caution/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "btki-ibrutinib-cardiac-caution" ;
  schema:name "Caution: ibrutinib in patients with cardiac risk"@en ;
  schema:description "Ibrutinib raises the risk of irregular heart rhythm, high blood pressure, and sudden cardiac events; second-generation BTK inhibitors are safer choices for patients with heart disease."@en ;
  schema:url <https://onco.cc/pairings/btki-ibrutinib-cardiac-caution/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03734016> ;
  onco:cancers <https://onco.cc/cancers/cll/> ;
  onco:technologies <https://onco.cc/technologies/cardio-oncology/> ;
  onco:drugs <https://onco.cc/drugs/ibrutinib/>, <https://onco.cc/drugs/acalabrutinib/>, <https://onco.cc/drugs/zanubrutinib/> ;
  onco:trials <https://onco.cc/trials/alpine/> ;
  onco:pairs <https://onco.cc/drugs/ibrutinib/>, <https://onco.cc/technologies/cardio-oncology/> .