# OnCo record cachexia-biology (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/cachexia-biology/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "cachexia-biology" ;
  schema:name "Cancer cachexia"@en ;
  schema:description "The wasting syndrome that kills up to a third of cancer patients: tumours send hormonal signals (GDF-15, IL-6) that switch off appetite and burn muscle and fat. The first drug to reverse it, ponsegromab, showed weight gain in 2024."@en ;
  schema:url <https://onco.cc/pathways/cachexia-biology/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cachexia> ;
  owl:sameAs <http://www.wikidata.org/entity/Q6003455> ;
  schema:citation <https://doi.org/10.1056/NEJMoa2409515> ;
  onco:tag "mechanism" ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/gastric/> ;
  onco:technologies <https://onco.cc/technologies/exercise-oncology/>, <https://onco.cc/technologies/geriatric-assessment/> ;
  onco:institutions <https://onco.cc/institutions/fred-hutch/>, <https://onco.cc/institutions/cold-spring-harbor/>, <https://onco.cc/institutions/md-anderson/> ;
  onco:pathways <https://onco.cc/pathways/jak-stat/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/pathways/cancer-metabolism/> .