# OnCo record caf-activation-desmoplasia (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/caf-activation-desmoplasia/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "caf-activation-desmoplasia" ;
  schema:name "Fibroblast activation, desmoplasia & matrix stiffness"@en ;
  schema:description "Tumours recruit the body's repair cells, fibroblasts, and keep them in wound-healing mode forever. The scar tissue they lay down (desmoplasia) squeezes blood vessels shut, walls out immune cells, stiffens the tissue in a way that itself tells cancer cells to grow, and is why pancreatic cancer is so hard to treat."@en ;
  schema:url <https://onco.cc/pathways/caf-activation-desmoplasia/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cancer-associated_fibroblast> ;
  schema:citation <https://doi.org/10.1038/s41568-019-0238-1>, <https://doi.org/10.1038/nrc.2016.73> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:technologies <https://onco.cc/technologies/fapi-pet/>, <https://onco.cc/technologies/stroma-directed-car/>, <https://onco.cc/technologies/mechanobiology-therapy/>, <https://onco.cc/technologies/radioligand-therapy/>, <https://onco.cc/technologies/single-cell-spatial/> ;
  onco:targets <https://onco.cc/targets/fap/>, <https://onco.cc/targets/smoothened/>, <https://onco.cc/targets/jak2/>, <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/fap-2286/>, <https://onco.cc/drugs/vismodegib/>, <https://onco.cc/drugs/sonidegib/>, <https://onco.cc/drugs/ruxolitinib/>, <https://onco.cc/drugs/avutometinib-defactinib/> ;
  onco:pathways <https://onco.cc/pathways/tumor-microenvironment/>, <https://onco.cc/pathways/tgf-beta/>, <https://onco.cc/pathways/hippo-yap/>, <https://onco.cc/pathways/hedgehog/>, <https://onco.cc/pathways/jak-stat/>, <https://onco.cc/pathways/immune-desert-exclusion/>, <https://onco.cc/pathways/invasion-ecm-degradation/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/>, <https://onco.cc/terms/cancer-associated-fibroblasts/>, <https://onco.cc/terms/immune-exclusion/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-tme-immunosuppression/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-kalluri-nat-rev-cancer/>, <https://onco.cc/key-papers/paper-sahai-nat-rev-cancer/> .