# OnCo record caf-subtypes-pancreatic (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/caf-subtypes-pancreatic/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "caf-subtypes-pancreatic" ;
  schema:name "Fibroblast subtypes in the pancreatic cancer stroma (myCAF, iCAF and apCAF)"@en ;
  schema:alternateName "CAF subtypes"@en, "myCAF"@en, "iCAF"@en, "apCAF"@en, "Myofibroblastic CAF"@en, "Inflammatory CAF"@en, "Antigen-presenting CAF"@en ;
  schema:description "The fibroblasts that make up most of a pancreatic tumour are not one cell type. Those pressed against the cancer cells become contractile myofibroblasts (myCAF), those further away secrete inflammatory signals (iCAF), and a third group carries antigen-presenting molecules (apCAF). The states are plastic, which is why stripping the stroma out failed and reprogramming it is the current idea."@en ;
  schema:url <https://onco.cc/terms/caf-subtypes-pancreatic/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://doi.org/10.1084/jem.20162024>, <https://doi.org/10.1158/2159-8290.CD-19-0094>, <https://doi.org/10.1016/j.cell.2021.09.022> ;
  onco:tag "pancreatic-molecular" ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/single-cell-spatial/>, <https://onco.cc/technologies/spatial-transcriptomics/>, <https://onco.cc/technologies/organoids/> ;
  onco:pathways <https://onco.cc/pathways/caf-activation-desmoplasia/>, <https://onco.cc/pathways/tumor-microenvironment/> ;
  onco:terms <https://onco.cc/terms/desmoplasia/>, <https://onco.cc/terms/immune-exclusion/>, <https://onco.cc/terms/cold-vs-hot/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-ohlund-caf-subtypes-mycaf-icaf-jem-2017/>, <https://onco.cc/key-papers/paper-elyada-antigen-presenting-cafs-single-cell-cancer-discov-2019/>, <https://onco.cc/key-papers/paper-grunwald-subtme-pancreatic-cell-2021/> .