# OnCo record calicheamicin (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/calicheamicin/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "calicheamicin" ;
  schema:name "Calicheamicin"@en ;
  schema:alternateName "ozogamicin payload"@en, "N-acetyl gamma calicheamicin"@en, "ozogamicin (N-acetyl-γ-calicheamicin)"@en ;
  schema:description "Calicheamicin is an enediyne antibiotic used as an antibody-drug conjugate payload: it binds the minor groove of DNA and cuts both strands at picomolar concentrations, about a thousand times more cytotoxic than conventional chemotherapy. That is why it is only given attached to an antibody (Mylotarg, Besponsa), and why liver toxicity, including veno-occlusive disease, is its defining risk."@en ;
  schema:url <https://onco.cc/terms/calicheamicin/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Calicheamicin> ;
  owl:sameAs <http://www.wikidata.org/entity/Q409744> ;
  schema:citation <https://en.wikipedia.org/wiki/Calicheamicin> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/gemtuzumab-ozogamicin/> ;
  onco:terms <https://onco.cc/terms/payload/>, <https://onco.cc/terms/dna-cleaver-payloads/> .