# OnCo record cancer-immunity-cycle (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/cancer-immunity-cycle/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "cancer-immunity-cycle" ;
  schema:name "The cancer-immunity cycle"@en ;
  schema:description "Seven steps the immune system must complete to kill a tumour: release of antigens, pick-up by dendritic cells, priming of T cells in lymph nodes, travel, entry into the tumour, recognition, and killing. Every immunotherapy pushes on one step; every escape blocks one."@en ;
  schema:url <https://onco.cc/pathways/cancer-immunity-cycle/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cancer_immunology> ;
  schema:citation <https://doi.org/10.1016/j.immuni.2013.07.012>, <https://doi.org/10.1038/nature21349> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/immune-surveillance-immunoediting/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/neoantigen-mrna-vaccine/>, <https://onco.cc/technologies/sting-agonist/>, <https://onco.cc/technologies/t-cell-engager/>, <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/oncolytic-virus/>, <https://onco.cc/technologies/sbrt/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/pdl1/>, <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/vegf/>, <https://onco.cc/targets/cd3/>, <https://onco.cc/targets/cd137/>, <https://onco.cc/targets/ido1/> ;
  onco:drugs <https://onco.cc/drugs/pembrolizumab/>, <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/>, <https://onco.cc/drugs/ivonescimab/>, <https://onco.cc/drugs/intismeran-autogene/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/antigen-presentation-immunoediting/>, <https://onco.cc/pathways/cgas-sting/>, <https://onco.cc/pathways/vegf-angiogenesis/> ;
  onco:terms <https://onco.cc/terms/neoantigen/>, <https://onco.cc/terms/immunogenic-cell-death/>, <https://onco.cc/terms/cold-vs-hot/>, <https://onco.cc/terms/tils/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-chen-nature/> .