# OnCo record cancer-stem-cell-theory (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/cancer-stem-cell-theory/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "cancer-stem-cell-theory" ;
  schema:name "Cancer stem cell theory and phenotypic plasticity"@en ;
  schema:alternateName "cancer stem cell hypothesis"@en, "CSC theory"@en, "hierarchical model of cancer"@en, "tumour-initiating cells"@en, "stochastic versus hierarchical model"@en, "plasticity model"@en ;
  schema:description "The idea that a tumour is organised like a tissue, with a small pool of stem-like cells that renew it and a bulk that cannot, so killing the bulk shrinks the tumour but the stem-like cells regrow it. Proved in leukaemia and real in some solid tumours, but the rigid hierarchy gave way to plasticity: ordinary tumour cells can slip back into the stem-like state, especially under treatment."@en ;
  schema:url <https://onco.cc/terms/cancer-stem-cell-theory/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cancer_stem_cell> ;
  schema:citation <https://doi.org/10.1038/367645a0>, <https://doi.org/10.1038/nm0797-730>, <https://doi.org/10.1038/35102167>, <https://doi.org/10.1038/nm0909-1010>, <https://doi.org/10.1038/nature07567>, <https://doi.org/10.1038/nm.4409> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/pathways/cancer-stem-cells-plasticity/>, <https://onco.cc/terms/epigenetic-progenitor-theory/>, <https://onco.cc/terms/clonal-evolution-theory/>, <https://onco.cc/terms/hallmarks-synthesis/>, <https://onco.cc/terms/unlocking-phenotypic-plasticity/>, <https://onco.cc/pathways/drug-tolerant-persisters/>, <https://onco.cc/pathways/lineage-plasticity-neuroendocrine/>, <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/wnt/>, <https://onco.cc/pathways/notch/>, <https://onco.cc/pathways/hedgehog/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/basal-cell-carcinoma/>, <https://onco.cc/cancers/glioblastoma/> ;
  onco:targets <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/menin/>, <https://onco.cc/targets/dll3/> ;
  onco:drugs <https://onco.cc/drugs/revumenib/>, <https://onco.cc/drugs/tarlatamab/>, <https://onco.cc/drugs/arsenic-trioxide/>, <https://onco.cc/drugs/vismodegib/> ;
  onco:pathways <https://onco.cc/pathways/cancer-stem-cells-plasticity/>, <https://onco.cc/pathways/drug-tolerant-persisters/>, <https://onco.cc/pathways/lineage-plasticity-neuroendocrine/>, <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/hedgehog/>, <https://onco.cc/pathways/notch/>, <https://onco.cc/pathways/wnt/> ;
  onco:people <https://onco.cc/people/john-dick/>, <https://onco.cc/people/irving-weissman/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-reya-cancer-stem-cells-nature-2001/>, <https://onco.cc/key-papers/paper-al-hajj-breast-cancer-stem-cells-pnas-2003/>, <https://onco.cc/key-papers/paper-singh-brain-tumour-initiating-cells-nature-2004/>, <https://onco.cc/key-papers/paper-lapidot-nature/>, <https://onco.cc/key-papers/paper-quintana-nature/>, <https://onco.cc/key-papers/paper-batlle-nat-med/>, <https://onco.cc/key-papers/paper-bonnet-nat-med/>, <https://onco.cc/key-papers/paper-gupta-nat-med/> .