# OnCo record cancer-stem-cells-plasticity (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/cancer-stem-cells-plasticity/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "cancer-stem-cells-plasticity" ;
  schema:name "Cancer stem cells & phenotypic plasticity"@en ;
  schema:description "Some cancer cells behave like stem cells: they can regrow the whole tumour, resist treatment, and switch identities. This plasticity explains why tumours come back and why some lung and prostate cancers transform into a different cancer type under therapy."@en ;
  schema:url <https://onco.cc/pathways/cancer-stem-cells-plasticity/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cancer_stem_cell> ;
  owl:sameAs <http://www.wikidata.org/entity/Q1638475> ;
  schema:citation <https://doi.org/10.1016/j.molcel.2020.10.033>, <https://doi.org/10.1158/2159-8290.CD-21-1059> ;
  onco:tag "mechanism" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/cancer-stem-cell-theory/> ;
  onco:targets <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/dll3/>, <https://onco.cc/targets/menin/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/tarlatamab/>, <https://onco.cc/drugs/revumenib/> ;
  onco:institutions <https://onco.cc/institutions/princess-margaret/>, <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/stanford/>, <https://onco.cc/institutions/francis-crick/> ;
  onco:pathways <https://onco.cc/pathways/emt/>, <https://onco.cc/pathways/wnt/>, <https://onco.cc/pathways/notch/>, <https://onco.cc/pathways/hedgehog/>, <https://onco.cc/pathways/swi-snf-chromatin/>, <https://onco.cc/pathways/clonal-evolution/> ;
  onco:terms <https://onco.cc/terms/unlocking-phenotypic-plasticity/>, <https://onco.cc/terms/histologic-transformation/>, <https://onco.cc/terms/lgr5/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-singh-brain-tumour-initiating-cells-nature-2004/>, <https://onco.cc/key-papers/paper-rubin-mol-cell/> .