# OnCo record carboplatin-calvert-dosing (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/carboplatin-calvert-dosing/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "carboplatin-calvert-dosing" ;
  schema:name "Carboplatin dosing by kidney function: the Calvert formula and how kidney function is measured"@en ;
  schema:alternateName "Calvert formula"@en, "carboplatin AUC dosing"@en, "AUC-based carboplatin dosing"@en, "dose = target AUC x (GFR + 25)"@en, "carboplatin GFR dosing"@en ;
  schema:description "Carboplatin is dosed by kidney function rather than body size, using a formula from 1989 that aims at a set drug exposure. The formula is only as good as the kidney measurement fed into it: in a study of 2,471 people with cancer, the usual blood-test estimates missed the intended dose by more than a fifth in about one person in five to one in four."@en ;
  schema:url <https://onco.cc/technologies/carboplatin-calvert-dosing/> ;
  schema:dateModified "2026-10-20"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.1989.7.11.1748>, <https://doi.org/10.1200/JCO.2017.72.7578>, <https://doi.org/10.1158/1078-0432.CCR-09-0017>, <https://doi.org/10.1002/jcsm.13469> ;
  onco:status "standard-of-care" ;
  onco:tag "precision", "evidence:moderate" ;
  onco:cancers <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/testicular/>, <https://onco.cc/cancers/head-and-neck/>, <https://onco.cc/cancers/breast-cancer/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/> ;
  onco:technologies <https://onco.cc/technologies/body-surface-area-dosing/>, <https://onco.cc/technologies/pkpd-modelling/>, <https://onco.cc/technologies/ct-body-composition-sarcopenia/> ;
  onco:drugs <https://onco.cc/drugs/carboplatin/> ;
  onco:terms <https://onco.cc/terms/pharmacokinetics/>, <https://onco.cc/terms/dose-modification/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-dose-optimisation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-calvert-j-clin-oncol/> .