# OnCo record cave (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/cave/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "cave", "NCT04561336" ;
  schema:name "CAVE mCRC"@en ;
  schema:alternateName "CAVE"@en ;
  schema:description "Adding a PD-L1 antibody to an EGFR antibody given a second time helped most in patients whose blood showed no resistance mutations, a seven-month difference in survival between the two groups."@en ;
  schema:url <https://onco.cc/trials/cave/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04561336>, <https://doi.org/10.1001/jamaoncol.2021.2915>, <https://doi.org/10.1016/j.esmogo.2026.100398> ;
  onco:status "positive" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/colorectal/> ;
  onco:technologies <https://onco.cc/technologies/monoclonal-antibody/>, <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/pd1/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/>, <https://onco.cc/drugs/avelumab/> ;
  onco:terms <https://onco.cc/terms/ctdna/>, <https://onco.cc/terms/msi/> ;
  onco:trials <https://onco.cc/trials/chronos/> .