# OnCo record cd123 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cd123/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cd123" ;
  schema:name "CD123"@en ;
  schema:description "CD123 is the interleukin-3 receptor alpha chain, present on every blastic plasmacytoid dendritic cell neoplasm and on the blasts and leukaemia stem cells of 70 to 80% of acute myeloid leukaemias. Tagraxofusp and pivekimab sunirine target it in that rare neoplasm, and CAR-T cells against it in AML must spare the normal blood-forming progenitors that also carry it."@en ;
  schema:url <https://onco.cc/targets/cd123/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Interleukin-3_receptor>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6012>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185291>, <https://www.uniprot.org/uniprotkb/P26951/entry>, <https://www.ncbi.nlm.nih.gov/gene/3563> ;
  owl:sameAs <http://www.wikidata.org/entity/Q21116062> ;
  schema:citation <https://en.wikipedia.org/wiki/Interleukin-3_receptor> ;
  onco:tag "adc-target" ;
  schema:alternateName "IL3RA" ;
  onco:targetClass "surface-antigen" ;
  onco:firstDescribed "1991"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/aml/> ;
  onco:drugs <https://onco.cc/drugs/pivekimab-sunirine/>, <https://onco.cc/drugs/tagraxofusp/> ;
  onco:companies <https://onco.cc/companies/orum-therapeutics/> .