# OnCo record cd28 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cd28/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cd28" ;
  schema:name "CD28"@en ;
  schema:alternateName "CD28 molecule"@en, "CD28 costimulatory receptor"@en, "CD28" ;
  schema:description "CD28 is the second signal a T cell needs before it attacks. Many CAR-T cells carry a piece of CD28 inside them to fire harder, ipilimumab works by stopping CTLA-4 from hogging CD28's partners, and a new bispecific antibody presses CD28 directly on T cells that are already bound to prostate cancer cells."@en ;
  schema:url <https://onco.cc/targets/cd28/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1653>, <https://www.uniprot.org/uniprotkb/P10747/entry>, <https://www.ncbi.nlm.nih.gov/gene/940> ;
  onco:tag "wave5-target" ;
  onco:targetClass "surface-antigen" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1653>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178562>, <https://www.uniprot.org/uniprotkb/P10747/entry>, <https://www.ncbi.nlm.nih.gov/gene/940> ;
  onco:related <https://onco.cc/drugs/ipilimumab/>, <https://onco.cc/drugs/axicabtagene-ciloleucel/>, <https://onco.cc/drugs/brexucabtagene-autoleucel/>, <https://onco.cc/drugs/lisocabtagene-maraleucel/>, <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/cd80/>, <https://onco.cc/targets/psma/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/dlbcl/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/bispecific-antibody/> ;
  onco:drugs <https://onco.cc/drugs/jnj-87189401/> ;
  onco:pathways <https://onco.cc/pathways/cancer-immunity-cycle/>, <https://onco.cc/pathways/pd1-checkpoint/> .