# OnCo record cd47-sirpa (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/cd47-sirpa/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "cd47-sirpa" ;
  schema:name "CD47 / SIRPα (the 'don't eat me' signal)"@en ;
  schema:description "Macrophages eat cells that look wrong unless the cell shows CD47, a 'don't eat me' badge that binds SIRP-alpha. Leukaemias, myelodysplastic syndromes, lymphomas and carcinomas overproduce CD47 to escape being eaten; antibodies that cover the badge work in the lab, but the leading drug, magrolimab, failed in blood cancers because red cells wear the same badge and lose it too."@en ;
  schema:url <https://onco.cc/pathways/cd47-sirpa/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/CD47> ;
  schema:citation <https://en.wikipedia.org/wiki/CD47> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/mds/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:targets <https://onco.cc/targets/cd47/> ;
  onco:drugs <https://onco.cc/drugs/magrolimab/> ;
  onco:pathways <https://onco.cc/pathways/antigen-presentation-immunoediting/>, <https://onco.cc/pathways/tumor-microenvironment/> ;
  onco:trials <https://onco.cc/drugs/magrolimab/> .