# OnCo record cd47 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cd47/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cd47" ;
  schema:name "CD47"@en ;
  schema:description "CD47 is the 'don't eat me' signal: it binds SIRP-alpha on macrophages to stop them engulfing the cell, and over 90% of AML blasts and large B-cell lymphoma cells display it. Blocking it should let macrophages eat tumour cells, but red cells carry CD47 too, so anaemia is built in, and the lead antibody magrolimab was dropped after failed trials."@en ;
  schema:url <https://onco.cc/targets/cd47/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/CD47>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1682>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196776>, <https://www.uniprot.org/uniprotkb/Q08722/entry>, <https://www.ncbi.nlm.nih.gov/gene/961> ;
  owl:sameAs <http://www.wikidata.org/entity/Q21108354> ;
  schema:citation <https://en.wikipedia.org/wiki/CD47>, <https://doi.org/10.1056/NEJMoa1807315> ;
  onco:tag "checkpoint", "innate", "failed-so-far" ;
  schema:alternateName "CD47" ;
  onco:targetClass "checkpoint" ;
  onco:firstDescribed "1992"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/cd47-blockade/> ;
  onco:drugs <https://onco.cc/drugs/peluntamig/>, <https://onco.cc/drugs/spevatamig/> ;
  onco:pathways <https://onco.cc/pathways/cd47-sirpa/> .