# OnCo record cd73-adenosine (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cd73-adenosine/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cd73-adenosine" ;
  schema:name "CD73 / adenosine axis"@en ;
  schema:description "CD73 is an enzyme on tumour and immune cells that converts AMP into adenosine, which switches off T and natural killer cells through A2A and A2B receptors. Oleclumab (anti-CD73) with durvalumab slowed progression in a phase 2 lung cancer trial and quemliclustat is in phase 3 in pancreatic cancer, but A2A blockers gave only modest signals and several were dropped."@en ;
  schema:url <https://onco.cc/targets/cd73-adenosine/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/5%27-nucleotidase>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8021>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135318>, <https://www.uniprot.org/uniprotkb/P21589/entry>, <https://www.ncbi.nlm.nih.gov/gene/4907> ;
  owl:sameAs <http://www.wikidata.org/entity/Q24775951> ;
  schema:citation <https://doi.org/10.1200/JCO.22.00227> ;
  onco:tag "gap-fill" ;
  schema:alternateName "NT5E" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1990"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/prostate/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/monoclonal-antibody/> ;
  onco:drugs <https://onco.cc/drugs/ak119/>, <https://onco.cc/drugs/mavrostobart/> ;
  onco:companies <https://onco.cc/companies/astrazeneca/>, <https://onco.cc/companies/gilead/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-herbst-j-clin-oncol/> .