# OnCo record cd79b-itam-mutation (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/cd79b-itam-mutation/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "cd79b-itam-mutation" ;
  schema:name "CD79B ITAM mutation"@en ;
  schema:alternateName "CD79B mutation"@en, "CD79B Y196"@en, "CD79A ITAM mutation"@en, "ITAM mutation"@en ;
  schema:description "A change in the signalling tail of part of the B-cell receptor that leaves the receptor switched on without needing anything to bind it. It marks a group of large B-cell lymphomas that depend on that signal, and therefore on the enzyme BTK."@en ;
  schema:url <https://onco.cc/biomarkers/cd79b-itam-mutation/> ;
  schema:dateModified "2026-09-30"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/nature08638>, <https://doi.org/10.1056/NEJMoa1801445> ;
  onco:tag "biomarker", "lymphoma" ;
  onco:related <https://onco.cc/terms/myd88-l265p/> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/primary-cns-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:technologies <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/cd79b/>, <https://onco.cc/targets/btk/>, <https://onco.cc/targets/myd88/> ;
  onco:drugs <https://onco.cc/drugs/ibrutinib/>, <https://onco.cc/drugs/polatuzumab-vedotin/> ;
  onco:pathways <https://onco.cc/pathways/bcr-signalling/>, <https://onco.cc/pathways/inflammation-nfkb/> ;
  onco:terms <https://onco.cc/terms/lymphoma-bio-lymphgen/>, <https://onco.cc/terms/cell-of-origin/>, <https://onco.cc/terms/ngs/> .