# OnCo record cd86 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cd86/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cd86" ;
  schema:name "CD86 (B7-2)"@en ;
  schema:alternateName "B7-2"@en, "B7.2"@en, "CD28LG2"@en, "CD86 molecule"@en, "CD86" ;
  schema:description "CD86 is one of the two B7 molecules on antigen-presenting cells that either wake a T cell up (through CD28) or calm it down (through CTLA-4). Ipilimumab works by stopping CTLA-4 from hogging CD86 and CD80."@en ;
  schema:url <https://onco.cc/targets/cd86/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1705>, <https://www.uniprot.org/uniprotkb/P42081/entry>, <https://www.ncbi.nlm.nih.gov/gene/942> ;
  onco:tag "checkpoint-map" ;
  onco:targetClass "checkpoint" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1705>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114013>, <https://www.uniprot.org/uniprotkb/P42081/entry>, <https://www.ncbi.nlm.nih.gov/gene/942> ;
  onco:related <https://onco.cc/targets/cd80/>, <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/cd28/>, <https://onco.cc/drugs/ipilimumab/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/cancer-immunity-cycle/> .