# OnCo record cdk4-6 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cdk4-6/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cdk4-6" ;
  schema:name "CDK4/6"@en ;
  schema:description "CDK4/6 is the engine that pushes a cell to copy its DNA. Blocking it alongside hormone therapy roughly doubled the time hormone-driven breast cancer stays controlled."@en ;
  schema:url <https://onco.cc/targets/cdk4-6/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_4> ;
  owl:sameAs <http://www.wikidata.org/entity/Q14911754> ;
  schema:citation <https://en.wikipedia.org/wiki/Cyclin-dependent_kinase_4> ;
  onco:tag "kinase" ;
  schema:alternateName "CDK4, CDK6" ;
  onco:targetClass "kinase" ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/sarcoma/> ;
  onco:drugs <https://onco.cc/drugs/tqb3616/> ;
  onco:pathways <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/er-signaling/>, <https://onco.cc/pathways/bladder-cancer-signalling/>, <https://onco.cc/pathways/breast-cancer-signalling/>, <https://onco.cc/pathways/glioma-signalling/>, <https://onco.cc/pathways/melanoma-signalling/>, <https://onco.cc/pathways/nsclc-signalling/>, <https://onco.cc/pathways/pancreatic-cancer-signalling/>, <https://onco.cc/pathways/sclc-signalling/> .