# OnCo record cdk46-plus-endocrine (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/cdk46-plus-endocrine/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "cdk46-plus-endocrine" ;
  schema:name "CDK4/6 inhibitor + endocrine therapy"@en ;
  schema:description "Cut the fuel (oestrogen) and jam the engine (CDK4/6) at the same time."@en ;
  schema:url <https://onco.cc/pairings/cdk46-plus-endocrine/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2305488> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/> ;
  onco:drugs <https://onco.cc/drugs/palbociclib/>, <https://onco.cc/drugs/ribociclib/>, <https://onco.cc/drugs/abemaciclib/> ;
  onco:pathways <https://onco.cc/pathways/er-signaling/>, <https://onco.cc/pathways/p53-cell-cycle/> ;
  onco:pairs <https://onco.cc/technologies/cdk46-inhibitor/>, <https://onco.cc/technologies/endocrine-therapy/> .