# OnCo record cell-cycle-engine-cdks (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/cell-cycle-engine-cdks/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "cell-cycle-engine-cdks" ;
  schema:name "The cell-cycle engine (cyclins & CDKs)"@en ;
  schema:description "Cell division runs on a clock made of cyclins and their kinases (CDKs), each pair firing in order: D-CDK4/6 to leave rest, E-CDK2 to start copying DNA, A-CDK2 to finish, B-CDK1 to divide. Cancers speed the clock; CDK inhibitors slow it."@en ;
  schema:url <https://onco.cc/pathways/cell-cycle-engine-cdks/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cyclin-dependent_kinase> ;
  schema:citation <https://doi.org/10.1038/nrc2602> ;
  onco:tag "mechanism", "mechanics-atlas" ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/sclc/>, <https://onco.cc/cancers/gallbladder/> ;
  onco:technologies <https://onco.cc/technologies/cdk46-inhibitor/>, <https://onco.cc/technologies/endocrine-therapy/> ;
  onco:targets <https://onco.cc/targets/cdk4-6/>, <https://onco.cc/targets/wee1/>, <https://onco.cc/targets/estrogen-receptor/>, <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/palbociclib/>, <https://onco.cc/drugs/ribociclib/>, <https://onco.cc/drugs/abemaciclib/>, <https://onco.cc/drugs/atirmociclib/> ;
  onco:pathways <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/er-signaling/>, <https://onco.cc/pathways/replication-stress/>, <https://onco.cc/pathways/mitotic-spindle-checkpoint/> ;
  onco:terms <https://onco.cc/terms/endocrine-resistance/>, <https://onco.cc/terms/evading-growth-suppressors/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-malumbres-nat-rev-cancer/> .