# OnCo record cell-of-origin (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/cell-of-origin/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "cell-of-origin" ;
  schema:name "Cell of origin (GCB vs ABC)"@en ;
  schema:alternateName "Hans algorithm"@en, "Hans classifier"@en, "Hans criteria"@en, "Lymph2Cx"@en, "GCB"@en, "ABC"@en, "non-GCB"@en, "germinal centre B-cell-like"@en, "activated B-cell-like"@en, "COO"@en, "LymphGen"@en ;
  schema:description "Whether a large B-cell lymphoma resembles a germinal-centre B cell or an activated B cell; the activated type does worse and depends on different pathways."@en ;
  schema:url <https://onco.cc/terms/cell-of-origin/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Diffuse_large_B-cell_lymphoma> ;
  schema:citation <https://doi.org/10.1038/35000501>, <https://doi.org/10.1182/blood-2003-05-1545>, <https://doi.org/10.1038/35000501>, <https://doi.org/10.1056/NEJMoa012914> ;
  onco:cancers <https://onco.cc/cancers/dlbcl/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/primary-cns-lymphoma/> ;
  onco:targets <https://onco.cc/targets/bcl2/>, <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/cd79b/>, <https://onco.cc/targets/myd88/>, <https://onco.cc/targets/crebbp/> ;
  onco:terms <https://onco.cc/terms/lymphoma-bio-cell-of-origin-in-practice/>, <https://onco.cc/terms/lymphoma-bio-lymphgen/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-alizadeh-nature/> .