# OnCo record cereblon (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/cereblon/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "cereblon" ;
  schema:name "Cereblon (CRBN)"@en ;
  schema:description "The protein that lenalidomide and pomalidomide latch onto. Bound drug changes which proteins the cell tags for destruction, degrading the myeloma transcription factors Ikaros and Aiolos."@en ;
  schema:url <https://onco.cc/targets/cereblon/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cereblon>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30185>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113851>, <https://www.uniprot.org/uniprotkb/Q96SW2/entry>, <https://www.ncbi.nlm.nih.gov/gene/51185> ;
  schema:citation <https://www.uniprot.org/uniprotkb/Q96SW2/entry> ;
  schema:alternateName "CRBN" ;
  onco:targetClass "other" ;
  onco:firstDescribed "2000"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/mds/> ;
  onco:technologies <https://onco.cc/technologies/celmods/> ;
  onco:drugs <https://onco.cc/drugs/lenalidomide/>, <https://onco.cc/drugs/pomalidomide/> .