# OnCo record checkmate-8hw (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/checkmate-8hw/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "checkmate-8hw", "NCT04008030" ;
  schema:name "CheckMate 8HW"@en ;
  schema:description "Showed that a two-drug immunotherapy combination controls mismatch-repair-deficient bowel cancer for over four years on average, and beats immunotherapy alone."@en ;
  schema:url <https://onco.cc/trials/checkmate-8hw/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04008030>, <https://www.nejm.org/doi/abs/10.1056/NEJMoa2402141>, <https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02848-4/abstract> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2019-08-05" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/msi-high-colorectal/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/ctla4/> ;
  onco:drugs <https://onco.cc/drugs/nivolumab/>, <https://onco.cc/drugs/ipilimumab/> ;
  onco:terms <https://onco.cc/terms/msi/> ;
  onco:trials <https://onco.cc/trials/nct05855200/> ;
  onco:people <https://onco.cc/people/thierry-andre/>, <https://onco.cc/people/heinz-josef-lenz/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-overman-checkmate-142-nivolumab-dmmr-colorectal-lancet-oncol-2017/>, <https://onco.cc/key-papers/paper-le-mmr-deficiency-pd1-nejm-2015/>, <https://onco.cc/key-papers/paper-andre-checkmate-8hw-nivolumab-ipilimumab-nejm-2024/> .