# OnCo record checkpoint (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/checkpoint/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "checkpoint" ;
  schema:name "Checkpoint (two meanings)"@en ;
  schema:alternateName "checkpoint"@en, "checkpoints"@en, "cell-cycle checkpoint"@en, "cell cycle checkpoint"@en, "cell-cycle checkpoints"@en, "checkpoint kinase"@en, "checkpoint kinases"@en ;
  schema:description "In cancer the word checkpoint means two unrelated things: a brake on immune cells that tumours press and checkpoint inhibitor drugs release, or a gate inside every dividing cell that stops it copying or splitting damaged DNA."@en ;
  schema:url <https://onco.cc/terms/checkpoint/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  onco:related <https://onco.cc/terms/immune-checkpoint/>, <https://onco.cc/terms/cell-cycle/>, <https://onco.cc/terms/synthetic-lethality/>, <https://onco.cc/terms/immuno-oncology/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/cdk46-inhibitor/>, <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/atr-chk1-inhibitors/> ;
  onco:targets <https://onco.cc/targets/pd1/>, <https://onco.cc/targets/ctla4/>, <https://onco.cc/targets/lag3/>, <https://onco.cc/targets/tim3/>, <https://onco.cc/targets/tigit/>, <https://onco.cc/targets/btla/>, <https://onco.cc/targets/vista/>, <https://onco.cc/targets/klrc1/>, <https://onco.cc/targets/kir2dl1/>, <https://onco.cc/targets/cd96/>, <https://onco.cc/targets/pvrig/>, <https://onco.cc/targets/pdl1/>, <https://onco.cc/targets/pdcd1lg2/>, <https://onco.cc/targets/cd80/>, <https://onco.cc/targets/cd86/>, <https://onco.cc/targets/hla-dra/>, <https://onco.cc/targets/fgl1/>, <https://onco.cc/targets/lgals9/>, <https://onco.cc/targets/ceacam1/>, <https://onco.cc/targets/pvr/>, <https://onco.cc/targets/nectin2/>, <https://onco.cc/targets/tnfrsf14/>, <https://onco.cc/targets/hla-e/>, <https://onco.cc/targets/cd47/>, <https://onco.cc/targets/sirpa/>, <https://onco.cc/targets/cd24/>, <https://onco.cc/targets/siglec10/>, <https://onco.cc/targets/lilrb1/>, <https://onco.cc/targets/lilrb2/>, <https://onco.cc/targets/cd28/>, <https://onco.cc/targets/icos/>, <https://onco.cc/targets/tnfrsf4/>, <https://onco.cc/targets/cd137/>, <https://onco.cc/targets/tnfrsf18/>, <https://onco.cc/targets/cd27/>, <https://onco.cc/targets/cd40/>, <https://onco.cc/targets/ido1/>, <https://onco.cc/targets/tdo2/>, <https://onco.cc/targets/cd73-adenosine/>, <https://onco.cc/targets/entpd1/>, <https://onco.cc/targets/adora2a/>, <https://onco.cc/targets/b7h3/>, <https://onco.cc/targets/b7h4/>, <https://onco.cc/targets/hhla2/>, <https://onco.cc/targets/tgfb1/>, <https://onco.cc/targets/il10/>, <https://onco.cc/targets/cdk4-6/>, <https://onco.cc/targets/ccnd1/>, <https://onco.cc/targets/rb1/>, <https://onco.cc/targets/cdkn2a/>, <https://onco.cc/targets/atr/>, <https://onco.cc/targets/chek1/>, <https://onco.cc/targets/wee1/>, <https://onco.cc/targets/plk1/>, <https://onco.cc/targets/atm/>, <https://onco.cc/targets/chek2/>, <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/parp/>, <https://onco.cc/targets/aurka/>, <https://onco.cc/targets/aurkb/>, <https://onco.cc/targets/ttk/>, <https://onco.cc/targets/bub1/> ;
  onco:pathways <https://onco.cc/pathways/pd1-checkpoint/>, <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/mitotic-spindle-checkpoint/> .