# OnCo record chek1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/chek1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "chek1" ;
  schema:name "CHEK1"@en ;
  schema:alternateName "checkpoint kinase 1"@en, "Serine/threonine-protein kinase Chk1"@en, "CHK1"@en, "CHEK1" ;
  schema:description "CHEK1 (Serine/threonine-protein kinase Chk1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Small-cell lung cancer."@en ;
  schema:url <https://onco.cc/targets/chek1/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1925>, <https://www.uniprot.org/uniprotkb/O14757/entry>, <https://www.ncbi.nlm.nih.gov/gene/1111>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149554> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1925>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149554>, <https://www.uniprot.org/uniprotkb/O14757/entry>, <https://www.ncbi.nlm.nih.gov/gene/1111> ;
  onco:related <https://onco.cc/collections/civic/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/sclc/> ;
  onco:pathways <https://onco.cc/pathways/ddr/>, <https://onco.cc/pathways/replication-stress/> .