# OnCo record chek2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/chek2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "chek2" ;
  schema:name "CHEK2"@en ;
  schema:alternateName "checkpoint kinase 2"@en, "Serine/threonine-protein kinase Chk2"@en, "CDS1"@en, "CHK2"@en, "HuCds1"@en, "PP1425"@en, "bA444G7"@en, "RAD53"@en, "CHEK2" ;
  schema:description "CHEK2 (Serine/threonine-protein kinase Chk2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Prostate cancer, Sarcomas and 5 more."@en ;
  schema:url <https://onco.cc/targets/chek2/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16627>, <https://www.uniprot.org/uniprotkb/O96017/entry>, <https://www.ncbi.nlm.nih.gov/gene/11200>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183765> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "kinase" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16627>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183765>, <https://www.uniprot.org/uniprotkb/O96017/entry>, <https://www.ncbi.nlm.nih.gov/gene/11200> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/thyroid/>, <https://onco.cc/cancers/gastric/> ;
  onco:pathways <https://onco.cc/pathways/homologous-recombination-repair/> .