# OnCo record chemoprevention-and-er-negative-breast-cancer (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/chemoprevention-and-er-negative-breast-cancer/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "chemoprevention-and-er-negative-breast-cancer" ;
  schema:name "Chemoprevention (tamoxifen, anastrozole, raloxifene) and ER-negative breast cancer"@en ;
  schema:alternateName "Breast cancer chemoprevention"@en, "Tamoxifen for prevention"@en, "Anastrozole for prevention"@en, "IBIS-I"@en, "IBIS-II"@en, "NSABP P-1"@en, "Preventive tamoxifen and BRCA1"@en ;
  schema:description "Tamoxifen and anastrozole taken for five years cut the number of new breast cancers in women at raised risk by a third to a half, and NICE offers them to women at high or moderate risk. But the cancers they prevent are oestrogen-driven ones; in the trials they made no difference to oestrogen receptor-negative cancers, the kind BRCA1 carriers mostly get."@en ;
  schema:url <https://onco.cc/terms/chemoprevention-and-er-negative-breast-cancer/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Tamoxifen> ;
  schema:citation <https://www.nice.org.uk/guidance/cg164/chapter/Recommendations>, <https://doi.org/10.1016/s1470-2045(14)71171-4>, <https://doi.org/10.1093/jnci/90.18.1371>, <https://doi.org/10.1016/s0140-6736(19)32955-1>, <https://doi.org/10.1200/jco.2012.47.8313>, <https://www.cancerresearchuk.org/about-cancer/breast-cancer/risks-causes/family-history-and-inherited-genes>, <https://doi.org/10.1093/jnci/dju237> ;
  onco:tag "breast", "tnbc" ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/brca-associated-tnbc/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/breast-cancer/> ;
  onco:technologies <https://onco.cc/technologies/chemoprevention/>, <https://onco.cc/technologies/endocrine-therapy/> ;
  onco:targets <https://onco.cc/targets/estrogen-receptor/> ;
  onco:drugs <https://onco.cc/drugs/tamoxifen/>, <https://onco.cc/drugs/anastrozole/>, <https://onco.cc/drugs/raloxifene/> ;
  onco:terms <https://onco.cc/terms/risk-reducing-surgery-brca-carriers/> .