# OnCo record choline-metabolism-in-cancer (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/choline-metabolism-in-cancer/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "choline-metabolism-in-cancer" ;
  schema:name "Choline metabolism in cancer"@en ;
  schema:alternateName "KEGG hsa05231"@en, "Choline metabolism in cancer"@en ;
  schema:description "This KEGG map shows how cancer cells rewire the handling of choline, a nutrient used to build cell membranes, so that growth signals and membrane building feed each other. It matters because the resulting build-up of phosphocholine is visible on MR spectroscopy and PET scans and is one of the metabolic hallmarks of cancer."@en ;
  schema:url <https://onco.cc/pathways/choline-metabolism-in-cancer/> ;
  schema:dateModified "2026-09-10"^^xsd:date ;
  schema:citation <https://www.kegg.jp/pathway/hsa05231>, <https://doi.org/10.1038/nrc3162> ;
  onco:related <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/hif-vhl/> ;
  onco:targets <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/kras/>, <https://onco.cc/targets/mtor/>, <https://onco.cc/targets/hif2a/> ;
  onco:drugs <https://onco.cc/drugs/alpelisib/>, <https://onco.cc/drugs/capivasertib/>, <https://onco.cc/drugs/everolimus/>, <https://onco.cc/drugs/trametinib/>, <https://onco.cc/drugs/belzutifan/> ;
  onco:pathways <https://onco.cc/pathways/cancer-metabolism/>, <https://onco.cc/pathways/pi3k-akt-mtor/>, <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/hif-vhl/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-glunde-nat-rev-cancer/> .